Sur le Web, ces 30 derniers jours

mardi 11 décembre 2018

  • Item 26 UE 2 - Prévention des risques fœtaux : infections, médicaments, toxiques, irradiation
    Infections bactériennes et grossesse; Pour comprendre; Infections par voie ascendante vaginale; Streptocoque du groupe B au cours de la grossesse; Infections transmises par voie transplacentaire hématogène; Tuberculose; Infections virales et toxoplasmose; Toxoplasmose; Infections virales; (...)

  • Synthèse - Conduites à tenir initiales devant des patientes atteintes d'un cancer épithélial de l'ovaire
  • Point de situation sur la sécurisation de l’accès aux médicaments dérivés du sang pour les patients dans un contexte de difficultés d’approvisionnement - Point d'Information
    Compte tenu des difficultés d’approvisionnement rencontrées avec plusieurs médicaments dérivés du sang produits par LFB Biomédicaments à la suite d’une coupure générale de leur fournisseur d’électricité, l’ANSM souhaite informer les patients et les professionnels de santé concernés de la couverture des (...)

  • Highlights for December 11, 2018
  • Institutional Conflicts of Interest and Public Trust
    This Viewpoint discusses recent problems with undisclosed conflicts of interest and proposes broadening disclosure requirements beyond individuals to include the institutions funding the research.

  • Should Failure to Disclose Significant Financial Conflicts of Interest Be Considered Research Misconduct?
    This Viewpoint proposes that failure of authors to completely disclose conflicts of interest (COIs) should be considered a form of research misconduct subject to institutional review and sanctions if appropriate to establish a basic standard of consistent COI (...)

  • Monitoring Jet Engines and the Health of People
    In this Viewpoint, Eric Topol and Lionel Tarrasenko, a biomedical engineer known for developing early-warning systems in critical care settings, contrast the precision monitoring of jet engines with existing monitoring systems in patients, and discuss how sensors, artificial intelligence, and (...)

  • Expansion of the Medicare 340B Payment Program
    In this Viewpoint, the authors review Medicare & Medicaid Services 340B Payment program and recent rules to curtail expansion of drug discounts beyond serving poor patients.

  • When Statistics Fail the Patient
    In this narrative medicine essay, a pediatrician and PhD-trained epidemiologist considers the personal significance of the statistically rare event that has happened to her and the implications for how she cares for patients and communicates risks to families confronting medical (...)

  • Conflicts of Interests, Authors, and Journals
    Conflict of interest affects virtually every aspect of medicine, including research, teaching, and clinical care. In May 2017, JAMA published a theme issue that included 23 articles on conflicts of interest (COIs) that represented “the multifaceted aspects and complexity of COI from numerous (...)

  • Vitamin D Receptor Agonists for Patients Undergoing Hemodialysis
    Cardiovascular disease (CVD) is the leading cause of death among patients with end-stage kidney disease (ESKD) who are undergoing hemodialysis, yet many standard cardioprotective therapies have not been effective in reducing CVD in this patient population. This reality has motivated the quest (...)

  • Intensive Intervention to Improve Outcomes for Patients With COPD
    Chronic obstructive pulmonary disease (COPD) is one of the most common chronic conditions contributing to morbidity and mortality. In 2016, it was the third leading cause of years of life lost and diasbility-adjusted life-years in the United States, with an estimated 164 000 deaths. Even with (...)

  • Effect of Oral Alfacalcidol on Patients Without Secondary Hyperparathyroidism Receiving Maintenance Hemodialysis
    This randomized, open-label, blinded end point randomized clinical trial examined the effect of oral alfacalcidol, a vitamin D receptor activator, on cardiovascular events in patients with cardiovascular kidney disease receiving (...)

  • Effect of Transitional Care and Long-term Self-management Support on Patients With COPD
    This randomized clinical trial compares the effects of a program combining transition and long-term self-management support vs transition support alone on 6-month hospitalizations and emergency department visits among patients with chronic obstructive pulmonary disease (...)

  • Effect of Mexiletine on Muscle Stiffness in Patients With Nondystrophic Myotonia
    This study uses a series of aggregated N-of-1 trials to investigate the effectiveness of mexiletine for treatment of muscle stiffness in adult patients with nondystrophic myotonia and compares results from this series with those from a previously conducted randomized clinical (...)

  • Association Between Titin Loss-of-Function Variants and Early-Onset Atrial Fibrillation
    This nested case-control study of patients with early-onset atrial fibrillation (AF) used large-scale, deep-coverage whole-genome sequencing to identify a loss-of-function variant in TTN, the gene encoding the rare nerve protein titin, as a genetic risk factor for early (...)

  • Bayesian Hierarchical Models
    This JAMA Guide to Statistics and Methods discusses the use, limitations, and interpretation of Bayesian hierarchical modeling, a statistical procedure that integrates information across multiple levels and uses prior information about likely treatment effects and their variability to estimate (...)

  • Treatment of Lower Extremity Superficial Thrombophlebitis
    This Clinical Evidence Synopsis summarizes a Cochrane review of randomized trials comparing the effects of treatment of lower extremity superficial thrombophlebitis on venous thromboembolism and major bleeding.

  • Serum Creatinine in the Critically Ill Patient With Sepsis
    Following esophageal resection for cancer, a 73-year-old man was admitted to the ICU with pneumonia and progressive acute respiratory failure, and he was placed on mechanical ventilation. At day 5, his creatinine level continued to increase. How would you (...)

  • Childbearing and Family Leave Policies for Resident Physicians at Top Training Institutions
    This study describes childbearing and family leave at 15 graduate medical education (GME)–sponsoring institutions affiliated with 12 US medical schools on top 10 lists for funding or ranking.

  • Specialty Board Leave Policies for Resident Physicians Requesting Parental Leave
    This study compares family and childbearing leave policies for resident physicians among American Board of Medical Specialty (ABMS) member organizations that set training duration requirements for US residency programs.

  • Is It Possible to Get a Flu Shot Too Early?
    This Medical News article examines the ongoing debate about whether people should begin getting immunized against influenza as soon as the vaccine becomes available.

  • A Smarter War on Drugs
    Since the United States first declared a war on drugs more than 40 years ago, the nation’s criminal justice system has largely implemented traditional strategies, including arrest, drug seizure, and incarceration. But the failure of such approaches alone has prompted an intense search for (...)

  • Mumps Outbreak Near Denver
    From late 2016 to early 2017, an outbreak of 47 cases of mumps occurred in the Denver metropolitan area, according to a CDC report.

  • PrEP Disparities
    Just 4.7% of US prescriptions for preexposure prophylaxis (PrEP) to prevent HIV transmission went to women in 2016, according to a CDC report.

  • Artificial Intelligence Tools for Sepsis and Cancer
    Researchers at Imperial College London are developing an artificial intelligence (AI) agent to help physicians select optimal fluid and vasopressor doses for adult patients with sepsis in intensive care units (ICUs).

  • Real-Time Visualization of Bacteria in Lungs
    A bedside diagnostic approach is needed for mechanically ventilated patients in intensive care who develop new pulmonary infiltrates on chest x-ray and have a differential diagnosis of pneumonia. These patients are regularly given broad-spectrum antibiotics before bacteria culture results are (...)

  • Third Molar Extraction and Persistent Use of Opioids
    To the Editor Dr Harbaugh and colleagues addressed an important issue as to whether the initial prescription of an opioid after wisdom tooth extraction leads to persistent use. The American Association of Oral and Maxillofacial Surgeons has been addressing this issue, including publishing a (...)

  • Third Molar Extraction and Persistent Use of Opioids—Reply
    In Reply Dr Ferguson and colleagues raised concerns about our study demonstrating an association between perioperative opioid prescribing and new persistent opioid use in opioid-naive adolescents and young adults undergoing third molar (wisdom tooth) (...)

  • Potential Harms of HIPAA
    To the Editor In their Viewpoint on misconceptions surrounding the Health Insurance Portability and Accountability Act (HIPAA) Privacy Rule, Dr Berwick and Ms Gaines provided an accurate diagnosis but offered a problematic prescription. There is little doubt that counterproductive HIPAA myths (...)

  • Potential Harms of HIPAA
    To the Editor Dr Berwick and Ms Gaines discussed potential harms of HIPAA, which has increased burdens for practitioners, staff, patients, and the US health care system.

  • Potential Harms of HIPAA—Reply
    In Reply The call by Mr and Dr Kels for more physician control and less external regulation of what information should be released is easy to understand given the current overreaching of HIPAA as (mis)interpreted by institutions. We doubt, however, that simply permitting organizations to (...)

  • Failure to Disclose Conflict of Interest
    To the Editor I write to take full responsibility for failing to report appropriate conflict of interest disclosures in articles published in JAMA and the JAMA Network journals between 2015 and 2018, including “Mutation Detection in Patients With Advanced Cancer by Universal Sequencing of (...)

  • Error in Data Presentation in Text and Table
    In the Original Investigation titled “Association of Hospital Participation in a Medicare Bundled Payment Program With Volume and Case Mix of Lower Extermity Joint Replacement Episodes,” published in the September 4, 2018, issue of JAMA, data in a table and in the Results section were incorrect. (...)

  • Incorrect Affiliation and Text Deletion
    The Editorial entitled “Medicare Bundled Payment Programs for Joint Replacement: Anatomy of a Successful Payment Reform,” published in the September 4, 2018, issue of JAMA, had an incorrect affiliation and included incorrect language. The affiliation should have read “University of Michigan School (...)

  • Incorrect Grant Number
    In the Original Investigation titled “Association Between Bariatric Surgery and Macrovascular Disease Outcomes in Patients With Type 2 Diabetes and Severe Obesity,” published in the October 16, 2018, issue of JAMA, there was an incorrect grant number listed in the acknowledgment section. The (...)

  • Missing Conflict of Interest Disclosure
    In the Preliminary Communication titled “Mutation Detection in Patients With Advanced Cancer by Universal Sequencing of Cancer-Related Genes in Tumor and Normal DNA vs Guideline-Based Germline Testing,” published in the September 5, 2017, issue of JAMA, conflict of interest disclosures were not (...)

  • The Alzheimer’s Poetry Project
    This Arts and Medicine essay describes the Alzheimer’s Poetry Project, a program that brings poets and facilitators to dementia care settings to reduce social isolation and nurture creative expression among older adults with cognitive (...)

  • Ancestors
    The molted wild feathers on my walls

  • The Progress of Preventive Medicine
    The most outstanding feature of the war from the medical standpoint has been the really remarkable results obtained in the prevention of disease. War on an unparalleled scale has been going on for more than four years, waged under conditions in themselves calculated to initiate and spread (...)

  • Rhytidectomy (Face-Lift Surgery)
    This JAMA Patient Page describes the rhytidectomy procedure.

  • JAMA
  • Arrêt de commercialisation de la lotion anti-poux Prioderm à la suite du renforcement de ses conditions de prescription - Point d'information
    Le médicament Prioderm est indiqué pour le traitement des poux du cuir chevelu. A l’occasion d’une révision de son Autorisation de mise sur le marché (AMM), l’ANSM a décidé de restreindre son utilisation, en rendant la prescription médicale obligatoire , et de renforcer les contre-indications et (...)

  • Phosphoneuros : recommandations de bon usage pour éviter une erreur médicamenteuse - Lettre aux professionnels de santé
    Des modifications de la posologie et de la pipette graduée pour administration orale ont été apportées à la spécialité PHOSPHONEUROS, solution buvable en gouttes (flacon de 120 ml). Ces changements font suite à des signalements d’erreurs médicamenteuses du PHOSPHONEUROS chez des nouveaux-nés, qui ont (...)

  • Résumé de l'examen de l'innocuité - Inhibiteurs de la tyrosine kinase du récepteur du facteur de croissance de l'endothélium vasculaire - Santé Canada
    Les inhibiteurs de la tyrosine kinase du récepteur du facteur de croissance de l'endothélium vasculaire (ITK du récepteur du FCEV) sont des médicaments sur ordonnance dont la vente est autorisée au Canada pour le traitement de divers types de cancers, dont le cancer du rein et du foie ainsi que le (...)

  • Protocole national pour le traitement d'une infection à Clamydia trachomatis ou à Neisseria gonorrhoeae chez une personne asymptomatique
    Ce protocole national est reconnu comme norme de pratique professionnelle par l'Ordre des infirmières et infirmiers du Québec (OIIQ) et le Collège des médecins du Québec (CMQ). Il a été réalisé en collaboration avec un groupe d'experts dans le domaine des infections transmissibles sexuellement et par le (...)

  • Bactériurie asymptomatique au cours de la grossesse
    Les recommandations étaient fondées sur l'équilibre global entre les avantages possibles et les inconvénients du dépistage, en évaluant les avantages potentiels par rapport à tout inconvénient. Dans l'ensemble, des données probantes de très faible qualité provenant de quatre études de cohorte (n 7 611) (...)

  • Évaluation de l’efficacité et de la sécurité de l'étiopathie
    L’étiopathie est une pratique exclusivement manuelle s’inspirant historiquement du reboutement. Créée et développée en France par Christian Trédaniel dans les années 1960, son postulat thérapeutique est de « prioriser la détermination de la cause d’une pathologie plutôt que s’en supprimer directement les (...)

  • YESCARTA axicabtagene ciloleucel
  • Les risques biologiques au travail
    Les agents biologiques, qui regroupent les bactéries, les champignons microscopiques, les virus et les parasites, sont présents dans de nombreux secteurs d'activité. Au contact des travailleurs, certains de ces agents peuvent être à l'origine de maladies. Après avoir présenté les connaissances (...)









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